NDAbout Nicolas
Drug hunter with more than 20 years of experience in Biotech/Pharma environment, I contributed to the identification of 13 preclinical candidates, of which 7 were evaluated in clinical trials, including GLPG1690/Ziritaxestat for the treatment of Idiopathic Pulmonary Fibrosis and GLPG3970 for the treatment of Ulcerative Colitis and other inflammatory/autoimmune diseases.
I have experience in several therapeutic areas including Immunology, Fibrosis, Oncology and Antibacterials.
My roles as Lead Chemist and then as Project Leader allowed me to develop a broad expertise in drug discovery including skills and strategies to tackle some of the multiple challenges on the way to identify new drugs from Hit identification to lead optimization and early preclinical development.
Co-author on 19 peer-reviewed publications and 2 book chapters
Co-inventor on 18 patent applications
French
Native or bilingual
English
Fluent
Can work on-site
St-Malo (up to 50km), Paris (up to 40km), Rennes (up to 30km), Nantes (up to 50km)
Experience
- Galapagos SASUProject LeaderBIOTECHSeptember 2017 - October 2025 (8 years and 1 month)Romainville, France- Project Leader in Therapeutic area, Drug Innovation, and Immunology departments- Driving of Immunology, Fibrosis and Oncology projects in Research department.- Supervision of research activities across disciplines from Hit selection until decision to develop preclinical candidates.- Reporting and interactions with Senior Management, Development teams and external partners.- Key achievements: 8 preclinical candidates including 3 clinical candidates evaluated in phase 2 (1 compound: GLPG3970, SIK inhibitor), and phase 1 (2 compounds including GLPG4399, SIK inhibitor)
- Galapagos SASUTeam Leader in Medicinal Chemistry/Lead ChemistBIOTECHMay 2009 - September 2017 (8 years and 4 months)Romainville, France- Team Leader in Medicinal Chemistry department with a role of Lead Chemist on discovery projects in Immunology, Fibrosis (including Cystic Fibrosis) and Oncology.- Driving chemistry activities on discovery projects in HF, H2L and LO stages up to preclinical candidate selection.- Management (up to 7 direct reports) and leadership of internal and outsourced chemistry teams (up to 15 chemists).- Regular cross-disciplinary interactions internally and with pharmaceutical partners (Janssen, Servier, GSK, Abbvie).- Key achievements: identification of 5 preclinical candidates including 3 clinical candidates evaluated in phase 3 (1 compound, Ziritaxestat, Autotaxin inhibitor), and phase 1 (2 compounds).- Distinction: Runner-up of the 2016 EFMC Prize for a Young Medicinal Chemist in Industry
- MutabilisSenior Scientist in Medicinal Chemistry DepartmentBIOTECHDecember 2004 - May 2009 (4 years and 5 months)Romainville, France- Design and synthesis of anti-infective agents with antibacterial properties or inhibiting virulence factors, directed towards Gram negative and/or Gram-positive bacteria.- Leadership of Medicinal Chemistry programs developed in house or outsourced to Contract Research Organizations.- Presentation and discussion of chemical and biological results at projects meetings- Key achievement: contribution to 1 clinical candidate evaluated in phase 1.
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Education
- Ph.D.University of Paris VI (Université Pierre et Marie Curie, France)2004Ph.D. in Organic Chemistry
- MasterChimie ParisTech - PSL2001Master degree in Chemistry
Skill set
Categories
- Other